The Jam Origin MIDI Guitar 2 works by using a specialized pickup system that captures the vibrations of the guitar strings and translates them into MIDI data. This data is then sent to a computer or other MIDI-compatible device, where it can be used to control a wide range of virtual instruments and effects. The guitar itself features a unique, hexaphonic pickup system that captures the vibrations of each string individually, allowing for precise and nuanced control over the sound.