Sasikumar has appeared in over 200 films throughout his career, with more than 150 films in Tamil. Some of his notable works include "Thangathirai", "Uthama Puthiran", "Raja Rani", and "Pallu Padama Paathuka". He has worked with prominent directors like P. Vasu, K. S. Sethumadhavan, and Bala.